Mouse, stop twisting my arm! The Evoluent line of mice has been around for 15 years now, but for those just feeling the onset of wrist and forearm fatigue from too much rolling and clicking, you can maybe put the kibosh on it by going vertical.
Evoluent's VerticalMouse design prevents forearm twisting with an ergonomic shape that supports your hand, and keeps it in a neutral position during use. Your grip stays relaxed and comfortable, rather than reminiscent of riding through an intersection in Bangalore. For those who already have wrist pain, Evoluent reports switching to a VerticalMouse can help relieve it.
The VerticalMouse has an adjustable pointer speed, with change button accessible without moving your hand. It comes in a range of variations, including wired and wireless, right- and left-handed, and standard and small sizes.